Transient Receptor Potential Channels and Regulation of Lung Endothelial Permeability
نویسندگان
چکیده
منابع مشابه
Redox regulation of transient receptor potential channels.
SIGNIFICANCE Environmental and endogenous reactive species such as reactive oxygen species (ROS), reactive nitrogen species (RNS), and other electrophiles are not only known to exert toxic effects on organisms, but are also emerging as molecules that mediate cell signaling responses. However, the mechanisms underlying this cellular redox signaling by reactive species remains largely uncharacter...
متن کاملRecent Developments in Vascular Endothelial Cell Transient Receptor Potential Channels Transient Receptor Potential Channels and Possible Functions in Cardiovascular Muscle
Among the 28 identified and unique mammalian TRP (transient receptor potential) channel isoforms, at least 19 are expressed in vascular endothelial cells. These channels appear to participate in a diverse range of vascular functions, including control of vascular tone, regulation of vascular permeability, mechanosensing, secretion, angiogenesis, endothelial cell proliferation, and endothelial c...
متن کاملRecent developments in vascular endothelial cell transient receptor potential channels.
Among the 28 identified and unique mammalian TRP (transient receptor potential) channel isoforms, at least 19 are expressed in vascular endothelial cells. These channels appear to participate in a diverse range of vascular functions, including control of vascular tone, regulation of vascular permeability, mechanosensing, secretion, angiogenesis, endothelial cell proliferation, and endothelial c...
متن کاملInhibition of endothelial cell Ca2+ entry and transient receptor potential channels by Sigma-1 receptor ligands
BACKGROUND AND PURPOSE The Sigma-1 receptor (Sig1R) impacts on calcium ion signalling and has a plethora of ligands. This study investigated Sig1R and its ligands in relation to endogenous calcium events of endothelial cells and transient receptor potential (TRP) channels. EXPERIMENTAL APPROACH Intracellular calcium and patch clamp measurements were made from human saphenous vein endothelial ...
متن کاملTransient receptor potential channels and vascular function.
TRP (transient receptor potential) channels play important roles in the regulation of normal and pathological cellular function. In the vasculature, TRP channels are present both in ECs (endothelial cells) and vascular SMCs (smooth muscle cells) and contribute to vasomotor control mechanisms in most vascular beds. Vascular TRP channels are activated by various stimuli, such as mechanical pertur...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pulmonary Circulation
سال: 2013
ISSN: 2045-8940,2045-8940
DOI: 10.1086/674765